About   Help   FAQ
Targeted Allele Detail
Symbol: Mapttm1(Mecp2)Jae
Name: microtubule-associated protein tau; targeted mutation 1, Rudolf Jaenisch
MGI ID: MGI:3043293
Synonyms: Tau-Mecp2 ki
Gene: Mapt  Location: Chr11:104122216-104222916 bp, + strand  Genetic Position: Chr11, 67.79 cM, cytoband E1
Germline Transmission:  Earliest citation of germline transmission: J:89593
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutation:    Insertion
Mapttm1(Mecp2)Jae expresses 1 gene
Mutation detailsThe mouse Mecp2 coding sequence, a modified Kozak sequence and a neo-cassette were placed in-frame into exon 1 of Mapt via homologous combination. The resulting fusion protein contained the first 31 amino acids of Mapt fused to Mecp2 and was highly expressed in the brain (in post-mitotic neurons), lung, and kidney. (J:89593)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapt Mutation:  425 strains or lines available
Original:  J:89593 Luikenhuis S, et al., Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6033-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.19
The Jackson Laboratory