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Notch1tm2Agt
Targeted Allele Detail
Nomenclature
Symbol: Notch1tm2Agt
Name: notch 1; targeted mutation 2, Michael Aguet
MGI ID: MGI:3043290
Synonyms: Notch1-
Gene: Notch1  Location: Chr2:26457903-26516663 bp, - strand  Genetic Position: Chr2, 18.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55400
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA 3.5 kb segment including the putative promoter and the exon encoding the signaling peptide were deleted via homologous recombination and Cre-recombinase mediated excison. (J:55400)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Notch1 Mutation:  31 strains or lines available
References
Original:  J:55400 Radtke F, et al., Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity. 1999 May;10(5):547-58
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory