About   Help   FAQ
Lwq17L6
QTL Variant Detail
Summary
QTL variant: Lwq17L6
Name: liver weight QTL 17; L6
MGI ID: MGI:3043108
QTL: Lwq17  Location: Chr10:12704051-84079784 bp  Genetic Position: Chr10, Syntenic
Variant
origin
Strain of Specimen:  L6
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers decreased liver weight compared to M16i. (J:87793)
Inheritance:    Dominant
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87793

Linkage analysis was performed on 552 10-week old male animals from a (M16i x L6)F2 intercross to identify QTLs associated with measurements of growth such as organ weight, growth rate, and adiposity. 63 polymorphic markers spanning the 19 autosomes wereused in the genome scan. Parental strain M16i is a long term selection line for rapid 3- and 6- week weight gain whereas parental strain L6 is a long term selection line for low 6-week body weight. A total of 50 significant QTLs (LOD>3.3) were mapped over15 chromosomes. More than 25% of loci mapped to mouse Chromosome 2.

On mouse Chromosome 10, QTLs for kidney weight percentage (Kidpq2), heart weight (Hrtq3), subcutaneous fat percentage (Scfpq1), liver weight (Lvrq4), and testis weight (Tesq3) were identified. Kidpq2 mapped to 11.8 cM (LOD=3.4) between D10Mit1 and D10Mit65 with L6-derived alleles conferring dominantly inherited decrease in kidney weight percentage. Hrtq3 mapped to 27.3 cM (LOD=4.2) between D10Mit1 and D10Mit65 with L6-derived alleles conferring dominantly inherited decrease in heart weight. The confidence interval of Hrtq3 spans 13.7 cM - 44.6 cM. Scfpq1 maps to 33.1 cM (LOD=3.9) between D10Mit1 and D10Mit65 with L6-derived alleles conferring dominantly inherited increase in subcutaneousfat percentage. The confidence interval of Scfpq1 spans 20.5 cM - 55.3 cM. Lvrq4 mapped to 37 cM (LOD=5.5) between D10Mit1 and D10Mit65 with L6-derived alleles conferring dominantly inherited decrease in liver weight. The confidence interval of Lvrq4 spans 26.3 cM - 53.2 cM. Tesq3 mapped to 69 cM (LOD=3.9) between D10Mit65 and D10Mit35a with L6-derived alleles conferring dominantly inherited increase in testis weight.

References
Original:  J:87793 Rocha JL, et al., A large-sample QTL study in mice: II. Body composition. Mamm Genome. 2004 Mar;15(2):100-13
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory