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Mc1re-J
Spontaneous Allele Detail
Nomenclature
Symbol: Mc1re-J
Name: melanocortin 1 receptor; recessive yellow Jackson
MGI ID: MGI:3042897
Gene: Mc1r  Location: Chr8:124133846-124137483 bp, + strand  Genetic Position: Chr8, 72.1 cM
Mutation
origin
Strain of Origin:  B6(C)-H2-Ab1bm12/KhEgJ
Mutation
description
Allele Type:    Spontaneous
Mutation:    Deletion
 
Mutation detailsThis mutation arose spontaneously at the Jackson Laboratory in 1998. It was shown to be an allele of Mc1r by a noncomplementation test with C57BL/6J-Mc1re/J. A single bp deletion at position 856 (NM_008559.2) that results in a frameshift and premature temrination after 10 codons (per. comm. Dr. Ian Jackson).
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mc1r Mutation:  35 strains or lines available
Notes
Unpublished data from Dr. Ian Jackson (The University of Edinburgh) found a single base pair deletion at position 856 (NM_008559.2) that results in a framshift at codon 143 (NP_032585.2) and termination after 10 codons.
References
Original:  J:90328 Samples RM, et al., A remutation to Mc1r named recessive yellow Jackson (e-J). MGI Direct Data Submission. 2004;
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory