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Neu1a
Allele Detail
Nomenclature
Symbol: Neu1a
Name: neuraminidase 1; a variant
MGI ID: MGI:3042795
Synonyms: Neu-1s
Gene: Neu1  Location: Chr17:34931253-34935953 bp, + strand  Genetic Position: Chr17, 18.48 cM
Mutation
origin
Strain of Origin:  SM/J
Mutation
description
Allele Type:    Not Applicable
Mutation:    Nucleotide substitutions
 
Mutation details
Inheritance:    Codominant
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Neu1 Mutation:  4 strains or lines available
Notes
Low activity determined by the Neu1a allele occurs in the SM/J inbred strain and in wild mice in the area of Ann Arbor, Michigan; all other inbred strains have high activity determined by the Neu1b allele. Heterozygotes have intermediate activity. Neuraminidase removes extra sialic acid residues from these enzymes. The defective neuraminidase of Neu1a> mice, by failing to remove the extra sialic acid, changes their electrophoretic mobility (J:6480). Level of activity of neuraminidase in activated T lymphocytes is also depressed in Neu1a/Neu1a mice (J:7976).

References
Original:  J:6899 Womack JE, et al., Mouse gene for neuraminidase activity (Neu-1) maps to the D end of H-2. Immunogenetics. 1982;16(2):177-80
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory