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Fkbp8tm1Tili
Targeted Allele Detail
Nomenclature
Symbol: Fkbp8tm1Tili
Name: FK506 binding protein 8; targeted mutation 1, Tiansen Li
MGI ID: MGI:3042750
Synonyms: Fkbp8-
Gene: Fkbp8  Location: Chr8:70527724-70535328 bp, + strand  Genetic Position: Chr8, 34.15 cM, cytoband C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89364
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4 through 6 were deleted and replaced with a neo cassette via homologous recombination. RT-PCR and immunoblot analysis confirmed the absence of RNA and protein expression in homozygotes. (J:89364)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fkbp8 Mutation:  15 strains or lines available
References
Original:  J:89364 Bulgakov OV, et al., FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues. Development. 2004 May;131(9):2149-59
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory