Rps6ka3^tm1.1Kry
Targeted Allele Detail

Summary

• Symbol: Rps6ka3^tm1.1Kry
• Name: ribosomal protein S6 kinase polypeptide 3; targeted mutation 1.1, Gerard Karsenty
• MGI ID: MGI:3042586
• Synonyms: mrsk2-KO, Rsk2^-
• Gene: Rps6ka3 Location: ChrX:158038652-158151240 bp, + strand Genetic Position: ChrX, 73.27 cM
• Alliance: Rps6ka3^tm1.1Kry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89403
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was disrupted by the insertion of a floxed neo cassette followed by 3 stop codons. The floxed cassette was removed via Cre-mediated excision, leaving a single loxP site followed by the stop codons. Western blot confirmed absence of protein in mutant cells. (J:89403)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rps6ka3 Mutation: 13 strains or lines available

References

• Original: J:89403 Yang X, et al., ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell. 2004 Apr 30;117(3):387-98
• All: 18 reference(s)