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Targeted Allele Detail
Symbol: Rps6ka3tm1.1Kry
Name: ribosomal protein S6 kinase polypeptide 3; targeted mutation 1.1, Gerard Karsenty
MGI ID: MGI:3042586
Synonyms: mrsk2-KO, Rsk2-
Gene: Rps6ka3  Location: ChrX:159210307-159368244 bp, + strand  Genetic Position: ChrX, 73.27 cM
Germline Transmission:  Earliest citation of germline transmission: J:89403
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 was disrupted by the insertion of a floxed neo cassette followed by 3 stop codons. The floxed cassette was removed via Cre-mediated excision, leaving a single loxP site followed by the stop codons. Western blot confirmed absence of protein in mutant cells. (J:89403)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rps6ka3 Mutation:  7 strains or lines available
Original:  J:89403 Yang X, et al., ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell. 2004 Apr 30;117(3):387-98
All:  13 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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