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Targeted Allele Detail
Symbol: Rps6ka3tm1Kry
Name: ribosomal protein S6 kinase polypeptide 3; targeted mutation 1, Gerard Karsenty
MGI ID: MGI:3042584
Gene: Rps6ka3  Location: ChrX:159255665-159368244 bp, + strand  Genetic Position: ChrX, 73.27 cM
Germline Transmission:  Earliest citation of germline transmission: J:89403
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA floxed neo cassette, as well as three stop codons in three different frames, was inserted into exon 2. Western blot indicated absence of normal protein in mutant cells. (J:89403)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rps6ka3 Mutation:  9 strains or lines available
Original:  J:89403 Yang X, et al., ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell. 2004 Apr 30;117(3):387-98
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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