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Targeted Allele Detail
Symbol: Stard3tm1Jfs
Name: START domain containing 3; targeted mutation 1, Jerome F Strauss III
MGI ID: MGI:3042568
Synonyms: MLN64-
Gene: Stard3  Location: Chr11:98358368-98381112 bp, + strand  Genetic Position: Chr11, 61.75 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:89362
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 10 - 13 were replaced with an IRES-lacZ-Neo fusion gene. This resulted in deletion of most of the StAR-related lipid transfer domain. A truncated 35 kDa protein consisting of exons 1 - 9 fused to exon 14 and containing a frame shift in exon 14 was detected by western blot analysis (J:89362)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stard3 Mutation:  20 strains or lines available
Original:  J:89362 Kishida T, et al., Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism. J Biol Chem. 2004 Apr 30;279(18):19276-85
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory