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Targeted Allele Detail
Symbol: Bmp10tm1Shou
Name: bone morphogenetic protein 10; targeted mutation 1, Weinian Shou
MGI ID: MGI:3042354
Synonyms: BMP10-
Gene: Bmp10  Location: Chr6:87428994-87437677 bp, + strand  Genetic Position: Chr6, 37.96 cM, cytoband D2
Absent vitelline vessels in the yolk sac, stalled vascular development at the primary capillary plexus stage, and arteriovenous malformation in Bmp10tm1Shou/Bmp10tm1Shou embryos

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:89476
Parent Cell Line:  CCE916 (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 and 2 were deleted and replaced with a PGK-neo cassette via homologous recombination. RT-PCR confirmed the absence of expression in homozygotes. (J:89476)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bmp10 Mutation:  13 strains or lines available
Original:  J:89476 Chen H, et al., BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development. 2004 May;131(9):2219-31
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory