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Amhr2tm3(cre)Bhr
Targeted Allele Detail
Nomenclature
Symbol: Amhr2tm3(cre)Bhr
Name: anti-Mullerian hormone type 2 receptor; targeted mutation 3, Richard R Behringer
MGI ID: MGI:3042214
Synonyms: Amh-mis-Cre, Amhr2cre, Amhr2cre, Amhr2-cre, Amhr-2/Cre
Gene: Amhr2  Location: Chr15:102445367-102454630 bp, + strand  Genetic Position: Chr15, 57.58 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89999
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsA cassette containing IRES-cre and an FRT-flanked neo cassette was inserted into exon 5 of the endogenous gene. Expression of functional cre recombinase was detected in both male and female gonads and in the Mullerian duct. Based on phenotypic similarity to previously described Amhr2 deficient mice, this allele is putatively null. (J:89999, J:118270)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Amhr2     Summary of all recombinase alleles driven by Amhr2.
 

Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Amhr2 Mutation:  9 strains or lines available
References
Original:  J:89999 Jamin SP, et al., Requirement of Bmpr1a for Mullerian duct regression during male sexual development. Nat Genet. 2002 Nov;32(3):408-10
All:  88 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory