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Nr1h2tm1Djm
Targeted Allele Detail
Nomenclature
Symbol: Nr1h2tm1Djm
Name: nuclear receptor subfamily 1, group H, member 2; targeted mutation 1, David J Mangelsdorf
MGI ID: MGI:3041856
Synonyms: LXRbeta-
Gene: Nr1h2  Location: Chr7:44549616-44553951 bp, - strand  Genetic Position: Chr7, 28.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64343
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a targeting vector replaced exons 5 and 6 with a neomycin resistance cassette creating a null allele. Exons 5 and 6 encode the DNA-binding and ligand-binding domains.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Nr1h2 Mutation:  14 strains or lines available
References
Original:  J:64343 Repa JJ, et al., Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers [see comments]. Science. 2000 Sep 1;289(5484):1524-9
All:  67 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory