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Targeted Allele Detail
Symbol: Ppargtm1.1Mtz
Name: peroxisome proliferator activated receptor gamma; targeted mutation 1.1, Daniel Metzger
MGI ID: MGI:3041450
Synonyms: PPARgammaL-
Gene: Pparg  Location: Chr6:115360951-115490399 bp, + strand  Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
Germline Transmission:  Earliest citation of germline transmission: J:89238
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsCre-mediated recombination of Ppargtm1Mtz excised the sequence between the most 5' and 3' LoxP sites, removing exons 1 and 2 and the floxed neo. Exon 1 contains the initiator methionine codon for the gamma 1 isoform and exon 2 encodes the first zinc finger of the DNA-binding domain for gamma 1 and gamma 2 isoforms. PCR confirmed recombination. (J:89238)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pparg Mutation:  26 strains or lines available
Original:  J:89238 Imai T, et al., Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse. Proc Natl Acad Sci U S A. 2004 Apr 30;101(13):4543-7
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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