About   Help   FAQ
Ppargtm1.1Mtz
Targeted Allele Detail
Nomenclature
Symbol: Ppargtm1.1Mtz
Name: peroxisome proliferator activated receptor gamma; targeted mutation 1.1, Daniel Metzger
MGI ID: MGI:3041450
Synonyms: PPARgammaL-
Gene: Pparg  Location: Chr6:115360951-115490399 bp, + strand  Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89238
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination of Ppargtm1Mtz excised the sequence between the most 5' and 3' LoxP sites, removing exons 1 and 2 and the floxed neo. Exon 1 contains the initiator methionine codon for the gamma 1 isoform and exon 2 encodes the first zinc finger of the DNA-binding domain for gamma 1 and gamma 2 isoforms. PCR confirmed recombination. (J:89238)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pparg Mutation:  26 strains or lines available
References
Original:  J:89238 Imai T, et al., Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse. Proc Natl Acad Sci U S A. 2004 Apr 30;101(13):4543-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/11/2017
MGI 6.10
The Jackson Laboratory