About   Help   FAQ
Dnase2atm1Aea
Targeted Allele Detail
Nomenclature
Symbol: Dnase2atm1Aea
Name: deoxyribonuclease II alpha; targeted mutation 1, Alan Eastman
MGI ID: MGI:3040926
Synonyms: DNase IIalpha -
Gene: Dnase2a  Location: Chr8:84908560-84922915 bp, + strand  Genetic Position: Chr8, 41.31 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89469
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe first five exons were replaced with a PGK-neomycin resistance gene via homologous recombination. The genetic disruption resulted in complete loss of acid endonuclease activity in mouse embryonic fibroblasts and E15.5 livers from homozygous mutant embryos. (J:89469)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dnase2a Mutation:  76 strains or lines available
References
Original:  J:89469 Krieser RJ, et al., Deoxyribonuclease IIalpha is required during the phagocytic phase of apoptosis and its loss causes perinatal lethality. Cell Death Differ. 2002 Sep;9(9):956-62
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory