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Targeted Allele Detail
Symbol: Dnase2atm1Aea
Name: deoxyribonuclease II alpha; targeted mutation 1, Alan Eastman
MGI ID: MGI:3040926
Synonyms: DNase IIalpha -
Gene: Dnase2a  Location: Chr8:84908755-84911703 bp, + strand  Genetic Position: Chr8, 41.31 cM
Germline Transmission:  Earliest citation of germline transmission: J:89469
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe first five exons were replaced with a PGK-neomycin resistance gene via homologous recombination. The genetic disruption resulted in complete loss of acid endonuclease activity in mouse embryonic fibroblasts and E15.5 livers from homozygous mutant embryos. (J:89469)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dnase2a Mutation:  86 strains or lines available
Original:  J:89469 Krieser RJ, et al., Deoxyribonuclease IIalpha is required during the phagocytic phase of apoptosis and its loss causes perinatal lethality. Cell Death Differ. 2002 Sep;9(9):956-62
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory