Tlr7^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Tlr7^tm1Flv
• Name: toll-like receptor 7; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:3040902
• Synonyms: Tlr7^-
• Gene: Tlr7 Location: ChrX:166087925-166113554 bp, - strand Genetic Position: ChrX, 78.31 cM, cytoband F5
• Alliance: Tlr7^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89257
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A cassette containing lacZ and floxed neo replaced a portion of exon 3. Northern blot analysis of mutant bone marrow-derived macrophages indicated no mRNA was present. Beta galactose staining showed expression of lacZ in mutant lymph nodes. (J:89257, J:102090)

Disease models

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr7 Mutation: 21 strains or lines available

References

• Original: J:89257 Lund JM, et al., Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5598-603
• All: 124 reference(s)