Tg(Atp4b-cre)1Jig
Transgene Detail

Summary

• Symbol: Tg(Atp4b-cre)1Jig
• Name: transgene insertion 1, Jeffrey I Gordon
• MGI ID: MGI:3040892
• Synonyms: HKCre
• Transgene: Tg(Atp4b-cre)1Jig Location: unknown
• Alliance: Tg(Atp4b-cre)1Jig page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Atp4b-cre)1Jig expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Atp4b (MGI:88114)

• Mutation details: Sequence encoding a nuclear localization signal and cre recombinase was adjoined to regulatory elements of the mouse Atp4b gene (nucleotides -1035 through +24). The construct also contained a sequence fragment from the human growth hormone gene (GH1) (nucleotides +3 through +2150). The transgene was expressed in the progenitors of acid-producing parietal cells. Expression was not observed in gastric enteroendocrine cells. (J:89240)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Atp4b (mouse) Summary of all recombinase alleles driven by Atp4b. Comparative matrix view of recombinase activities Alliance mouse Atp4b gene page

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:89240 Syder AJ, et al., A transgenic mouse model of metastatic carcinoma involving transdifferentiation of a gastric epithelial lineage progenitor to a neuroendocrine phenotype. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4471-6
• All: 17 reference(s)