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Targeted Allele Detail
Symbol: Pomctm1Sora
Name: pro-opiomelanocortin-alpha; targeted mutation 1, S O'Rahilly
MGI ID: MGI:3040514
Synonyms: Pomc-
Gene: Pomc  Location: Chr12:3954951-3960642 bp, + strand  Genetic Position: Chr12, 1.99 cM
Germline Transmission:  Earliest citation of germline transmission: J:89244
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe majority of exon 3 was replaced with a tau-lacZ reporter and a floxed PGK-neo cassette. A point mutation was introduced into the initiator ATG to create a stop codon. X-gal staining showed beta-galactosidase activity was present in mutant brains. Endogenous mRNA was absent as shown by Northern blot, and a two-site immunoassay confirmed that no peptides were detected in mutant plasma. (J:89244)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pomc Mutation:  12 strains or lines available
Original:  J:89244 Challis BG, et al., Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36). Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4695-700
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory