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Targeted Allele Detail
Symbol: Pnpla6tm1Mvc
Name: patatin-like phospholipase domain containing 6; targeted mutation 1, Moses V Chao
MGI ID: MGI:3040330
Synonyms: Ntefl, NTEfl, Nteflox
Gene: Pnpla6  Location: Chr8:3515384-3544267 bp, + strand  Genetic Position: Chr8, 1.92 cM
Germline Transmission:  Earliest citation of germline transmission: J:89288
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsFloxed exons 2-5 remained following the excision of a floxed neomycin resistance gene in the 5' UTR by transient Cre expression. Western blot analysis of homozygous mutant brains indicated protein was present at wild-type levels. (J:89288)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pnpla6 Mutation:  7 strains or lines available
Original:  J:89288 Akassoglou K, et al., Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5075-80
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory