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Serpinb5tm1Zha
Targeted Allele Detail
Nomenclature
Symbol: Serpinb5tm1Zha
Name: serine (or cysteine) peptidase inhibitor, clade B, member 5; targeted mutation 1, Ming Zhang
MGI ID: MGI:3040188
Synonyms: Mp-
Gene: Serpinb5  Location: Chr1:106861180-106883348 bp, + strand  Genetic Position: Chr1, 50.34 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89192
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 7, encoding the reactive center loop, part of intron 6 and the entire 3' UTR were replaced with a neomycin resistance gene by homologous recombination. There was no transcript present in RT-PCR analysis of mutant embryoid bodies. (J:89192)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Serpinb5 Mutation:  3 strains or lines available
References
Original:  J:89192 Gao F, et al., Maspin plays an essential role in early embryonic development. Development. 2004 Apr;131(7):1479-89
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory