Serpinb5^tm1Zha
Targeted Allele Detail

Nomenclature

• Symbol: Serpinb5^tm1Zha
• Name: serine (or cysteine) peptidase inhibitor, clade B, member 5; targeted mutation 1, Ming Zhang
• MGI ID: MGI:3040188
• Synonyms: Mp^-
• Gene: Serpinb5 Location: Chr1:106861180-106883348 bp, + strand Genetic Position: Chr1, 50.34 cM

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89192
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 7, encoding the reactive center loop, part of intron 6 and the entire 3' UTR were replaced with a neomycin resistance gene by homologous recombination. There was no transcript present in RT-PCR analysis of mutant embryoid bodies. (J:89192)

Expression

In Structures Affected by this Mutation:

3 anatomical structures

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Serpinb5 Mutation: 3 strains or lines available

References

• Original: J:89192 Gao F, et al., Maspin plays an essential role in early embryonic development. Development. 2004 Apr;131(7):1479-89
• All: 3 reference(s)