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Prm2tm1Eddy
Targeted Allele Detail
Summary
Symbol: Prm2tm1Eddy
Name: protamine 2; targeted mutation 1, Edward M Eddy
MGI ID: MGI:3039800
Gene: Prm2  Location: Chr16:10609241-10609969 bp, - strand  Genetic Position: Chr16, 5.84 cM
Alliance: Prm2tm1Eddy page
Mutation
origin
Mouse Generated:  Earliest citation of chimera generation: J:69127
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced 66 bp in exon 1 via homologous recombination. Analysis of 129 derived sperm from chimeras showed reduced PRM1 and PRM2 protein expression. (J:69127)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prm2 Mutation:  8 strains or lines available
Notes
ES cell line was either R1 or BK4. Haploinsufficiency of Prm2 prevents genetic transmission of the mutated allele and generation of non-chimeric heterozygous mice. All phenotype data reported are from chimeric mice.
References
Original:  J:69127 Cho C, et al., Haploinsufficiency of protamine-1 or -2 causes infertility in mice. Nat Genet. 2001 May;28(1):82-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory