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Ctnnb1tm1(Nfkbia)Rsu
Targeted Allele Detail
Summary
Symbol: Ctnnb1tm1(Nfkbia)Rsu
Name: catenin beta 1; targeted mutation 1, Ruth Schmidt-Ullrich
MGI ID: MGI:3039783
Synonyms: cIkappaBalphadeltaN
Gene: Ctnnb1  Location: Chr9:120762466-120789573 bp, + strand  Genetic Position: Chr9, 72.19 cM
Alliance: Ctnnb1tm1(Nfkbia)Rsu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71744
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Ctnnb1tm1(Nfkbia)Rsu expresses 1 gene
 
Mutation detailsAn Nfkbia cDNA fragment encoding amino acids 71 through 317 of Nfkbia was inserted at start codon of the endogenous gene. The coding region of the first coding exon and the following 4 downstream exons were replaced by the inserted sequences. The encoded mutant Nfkbia protein was expressed in most tissues, lacked the N-terminal destruction box degradation signal, and has been previously shown to inhibit Nfkb1. (J:71744)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 5 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctnnb1 Mutation:  49 strains or lines available
References
Original:  J:71744 Schmidt-Ullrich R, et al., Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices. Development. 2001 Oct;128(19):3843-53
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory