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Transgene Detail
Symbol: Tg(Mt1-RET)304Ina
Name: transgene insertion 304, Izumi Nakashima
MGI ID: MGI:3039777
Synonyms: MT-ret
Transgene: Tg(Mt1-RET)304Ina  Location: unknown  
Strain of Origin:  (BALB/c x C57BL/6) X BALB/c
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsHuman RET proto-oncogene cDNA driven by the mouse metallothionein 1 promoter/enhancer. This mouse is predicted to have 5 copies of the transgene. Northern blot analysis revealed high levels of transgene expression in tumors and varying levels in melanin-producing cells of other tissues in mice of this line, including skin, muscle and Harderian glands. (J:70622)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Founder only. Lines 304a, 304b, and 304c were derived from this mouse. Additional founder numbers: 108, 192, 207, 242, 301, 319.
Phenotypic Similarity to Human Syndrome: Giant Congenital Melanocytic Nevus (J:50392)
Phenotypic Similarity to Human Syndrome: multistep melanoma (Tg(Mt1-RET)304Ina/0 in J:155735)
Phenotypic Similarity to Human Syndrome: de novo melanoma (for Ednrbtm1Ywa/Ednrb+ Tg(Mt1-RET)304Ina/0 in J:155735)

Original:  J:70622 Iwamoto T, et al., Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene. EMBO J. 1991 Nov;10(11):3167-75
All:  31 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory