About   Help   FAQ
Tg(Mt1-RET)304Ina
Transgene Detail
Nomenclature
Symbol: Tg(Mt1-RET)304Ina
Name: transgene insertion 304, Izumi Nakashima
MGI ID: MGI:3039777
Synonyms: MT-ret
Transgene: Tg(Mt1-RET)304Ina  Location: unknown  
Transgene
origin
Strain of Origin:  (BALB/c x C57BL/6) X BALB/c
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsHuman RET proto-oncogene cDNA driven by the mouse metallothionein 1 promoter/enhancer. This mouse is predicted to have 5 copies of the transgene. Northern blot analysis revealed high levels of transgene expression in tumors and varying levels in melanin-producing cells of other tissues in mice of this line, including skin, muscle and Harderian glands. (J:70622)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Notes
Founder only. Lines 304a, 304b, and 304c were derived from this mouse. Additional founder numbers: 108, 192, 207, 242, 301, 319.
References
Original:  J:70622 Iwamoto T, et al., Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene. EMBO J. 1991 Nov;10(11):3167-75
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/14/2022
MGI 6.19
The Jackson Laboratory