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Targeted Allele Detail
Symbol: Card11tm1Litt
Name: caspase recruitment domain family, member 11; targeted mutation 1, Dan R Littman
MGI ID: MGI:3039682
Synonyms: CARMA1-, carma1FN
Gene: Card11  Location: Chr5:140872990-141000582 bp, - strand  Genetic Position: Chr5, 79.42 cM
Germline Transmission:  Earliest citation of germline transmission: J:89322
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA single loxP site was inserted into intron 2 and a loxP-flanked neomycin selection cassette was inserted into intron 4 through homologous recombination. Western blot analysis on extracts derived from splenocytes of homozygous mice confirmed that no detectable protein was expressed from this allele. (J:89322)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Card11 Mutation:  7 strains or lines available
Original:  J:89322 Egawa T, et al., Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol. 2003 Jul 15;13(14):1252-8
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory