Tg(HRAS)2Jic
Transgene Detail

Summary

• Symbol: Tg(HRAS)2Jic
• Name: transgene insertion 2, Central Institute for Experimental Animals, Japan
• MGI ID: MGI:3039548
• Synonyms: rasH2, Tg(HRAS)2Mok, Tg rasH2, transgene insertion 2, CIEA
• Transgene: Tg(HRAS)2Jic Location: unknown
• Alliance: Tg(HRAS)2Jic page

Transgene origin

• Strain of Origin: (C57BL/6 x BALB/c)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Human HRAS genomic fragment containing 2.4 kb of 5'and 4.4 kb of 3' flanking sequences; the gene is wild-type except for a point mutation in the last intron which causes elevated expression levels. The human v-Ha-ras Harvey rat sarcoma viral oncogene homolog promoter controls expression of the transgene. (J:64968)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(HRAS)2Jic

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available

References

• Original: J:64968 Saitoh A, et al., Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes. Oncogene. 1990 Aug;5(8):1195-200
• All: 61 reference(s)