About   Help   FAQ
Tg(HRAS)2Jic
Transgene Detail
Nomenclature
Symbol: Tg(HRAS)2Jic
Name: transgene insertion 2, CIEA
MGI ID: MGI:3039548
Synonyms: rasH2, Tg(HRAS)2Mok, Tg rasH2
Transgene: Tg(HRAS)2Jic  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x BALB/c)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsHuman HRAS genomic fragment containing 2.4 kb of 5'and 4.4 kb of 3' flanking sequences; the gene is wild-type except for a point mutation in the last intron which causes elevated expression levels. The human v-Ha-ras Harvey rat sarcoma viral oncogene homolog promoter controls expression of the transgene. (J:64968)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
References
Original:  J:64968 Saitoh A, et al., Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes. Oncogene. 1990 Aug;5(8):1195-200
All:  60 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/18/2019
MGI 6.14
The Jackson Laboratory