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Cdkn1atm2(HBx)Xya
Targeted Allele Detail
Nomenclature
Symbol: Cdkn1atm2(HBx)Xya
Name: cyclin-dependent kinase inhibitor 1A (P21); targeted mutation 2, Xiao Yang
MGI ID: MGI:3039363
Synonyms: p21HBx
Gene: Cdkn1a  Location: Chr17:29090979-29100722 bp, + strand  Genetic Position: Chr17, 15.12 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88078
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 2 was replaced with a floxed neo cassette and sequence encoding the hepatitis B virus surface antigen (HBx). Endogenous transcript was undetected by RT-PCR analysis of homozygous mutant mice. (J:88078)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdkn1a Mutation:  48 strains or lines available
References
Original:  J:88078 Wang Y, et al., HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice. Hepatology. 2004 Feb;39(2):318-24
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory