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Selltm1Flv
Targeted Allele Detail
Nomenclature
Symbol: Selltm1Flv
Name: selectin, lymphocyte; targeted mutation 1, Richard A Flavell
MGI ID: MGI:3039283
Synonyms: CD62L-
Gene: Sell  Location: Chr1:164061982-164084181 bp, + strand  Genetic Position: Chr1, 71.37 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89253
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced 5.5 kb encoding the Sell domain via homologous recombination. Flow cytometry confirmed the absence of protein expression in peripheral blood leukocytes. (J:89253)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sell Mutation:  29 strains or lines available
References
Original:  J:89253 Xu J, et al., Impaired primary T cell responses in L-selectin-deficient mice. J Exp Med. 1996 Feb 1;183(2):589-98
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory