Tg(Tec-BCR/ABL1)5Hhi
Transgene Detail

Summary

• Symbol: Tg(Tec-BCR/ABL1)5Hhi
• Name: transgene insertion 5, Hisamaru Hirai
• MGI ID: MGI:3039034
• Transgene: Tg(Tec-BCR/ABL1)5Hhi Location: unknown
• Alliance: Tg(Tec-BCR/ABL1)5Hhi page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tec-BCR/ABL1)5Hhi expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ABL1 (25)

  Abl1	(MGI:87859)

  human

  BCR (613)

  Bcr	(MGI:88141)

• Tg(Tec-BCR/ABL1)5Hhi expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tec (MGI:98662)

• Mutation details: Fusion gene of human BCR and ABL1 encoding an oncogenic 210 kDa protein (p210^BCR/ABL). Expression of the cDNA is controlled by the mouse Tec promoter. (J:46392)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(Tec-BCR/ABL1)5Hhi

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:46392 Honda H, et al., Development of acute lymphoblastic leukemia and myeloproliferative disorder in transgenic mice expressing p210bcr/abl: a novel transgenic model for human Ph1-positive leukemias. Blood. 1998 Mar 15;91(6):2067-75
• All: 7 reference(s)