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Fgl2tm1Stsm
Targeted Allele Detail
Nomenclature
Symbol: Fgl2tm1Stsm
Name: fibrinogen-like protein 2; targeted mutation 1, Stephen T Smiley
MGI ID: MGI:3038987
Gene: Fgl2  Location: Chr5:21372642-21378374 bp, + strand  Genetic Position: Chr5, 9.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88648
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced both exons via homologous recombination. Western blot analysis confirmed the absence of secreted protein expression in stimulated macrophages from homozygotes (J:88648)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgl2 Mutation:  9 strains or lines available
References
Original:  J:88648 Hancock WW, et al., Intact type 1 immunity and immune-associated coagulative responses in mice lacking IFN gamma-inducible fibrinogen-like protein 2. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3005-10
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory