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Calcrtm1Dgal
Targeted Allele Detail
Summary
Symbol: Calcrtm1Dgal
Name: calcitonin receptor; targeted mutation 1, D L Galson
MGI ID: MGI:3038975
Synonyms: Calcr-, CTR -
Gene: Calcr  Location: Chr6:3685680-3764714 bp, - strand  Genetic Position: Chr6, 1.81 cM
Alliance: Calcrtm1Dgal page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92983
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsHomologous recombination was used to replace exons 6 and 7 with a neomycin cassette in the reverse orientation to the endogenous allele. Real time PCR demonstrated that expression of heterozygous osteoclasts was decreased compared with that of wild-type. (J:92983)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Calcr Mutation:  58 strains or lines available
References
Original:  J:92983 Laplace C, et al., (Homozygous deletion of the murine calcitonin receptor gene is an embryonic lethal). Abstracts of the 24th Annual Meeting of the American Society for Bone and Mineral Research. San Antonio, Texas, USA. September 20-24, 2002. J Bone Miner Res. 2002;17 Suppl 1:S125-541 (S143)
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory