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Targeted Allele Detail
Symbol: Sigirrtm1Mant
Name: single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; targeted mutation 1, Alberto Mantovani
MGI ID: MGI:3038878
Synonyms: Tir8-, TIR8-
Gene: Sigirr  Location: Chr7:141091175-141100572 bp, - strand  Genetic Position: Chr7, 86.35 cM
Germline Transmission:  Earliest citation of germline transmission: J:88907
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsHomologous recombination was used to insert IRES-LacZ followed by a PGK-neo cassette into exon 2, 51 bp 3' of the first ATG. No transcript was detected in mutant mice from the kidney or colon. (J:88907)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sigirr Mutation:  19 strains or lines available
Original:  J:88907 Garlanda C, et al., Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3522-6
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory