About   Help   FAQ
Sigirrtm1Mant
Targeted Allele Detail
Nomenclature
Symbol: Sigirrtm1Mant
Name: single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; targeted mutation 1, Alberto Mantovani
MGI ID: MGI:3038878
Synonyms: Tir8-, TIR8-
Gene: Sigirr  Location: Chr7:141091175-141100572 bp, - strand  Genetic Position: Chr7, 86.35 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88907
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsHomologous recombination was used to insert IRES-LacZ followed by a PGK-neo cassette into exon 2, 51 bp 3' of the first ATG. No transcript was detected in mutant mice from the kidney or colon. (J:88907)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sigirr Mutation:  18 strains or lines available
References
Original:  J:88907 Garlanda C, et al., Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3522-6
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/21/2017
MGI 6.08
The Jackson Laboratory