About   Help   FAQ
Chek2tm1Nmt
Targeted Allele Detail
Nomenclature
Symbol: Chek2tm1Nmt
Name: checkpoint kinase 2; targeted mutation 1, Noboru Motoyama
MGI ID: MGI:3038822
Synonyms: Chk2-
Gene: Chek2  Location: Chr5:110839979-110874145 bp, + strand  Genetic Position: Chr5, 53.73 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88888
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 6 kb region including exons 2 to 5 was deleted and replaced via homologous recombination with a neo cassette. Northern blot analysis confirmed the absence of mRNA in homozygotes. (J:88888)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chek2 Mutation:  35 strains or lines available
References
Original:  J:88888 Takai H, et al., Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J. 2002 Oct 1;21(19):5195-205
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/10/2017
MGI 6.10
The Jackson Laboratory