Chek2^tm1Nmt
Targeted Allele Detail

Summary

• Symbol: Chek2^tm1Nmt
• Name: checkpoint kinase 2; targeted mutation 1, Noboru Motoyama
• MGI ID: MGI:3038822
• Synonyms: Chk2^-
• Gene: Chek2 Location: Chr5:110987845-111022011 bp, + strand Genetic Position: Chr5, 53.73 cM, cytoband F
• Alliance: Chek2^tm1Nmt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88888
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 6 kb region including exons 2 to 5 was deleted and replaced via homologous recombination with a neo cassette. Northern blot analysis confirmed the absence of mRNA in homozygotes. (J:88888)

Tumor Data

List all tumor models in MMHCdb carrying Chek2^tm1Nmt

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chek2 Mutation: 53 strains or lines available

References

• Original: J:88888 Takai H, et al., Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J. 2002 Oct 1;21(19):5195-205
• All: 19 reference(s)