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Chek2tm1Nmt
Targeted Allele Detail
Nomenclature
Symbol: Chek2tm1Nmt
Name: checkpoint kinase 2; targeted mutation 1, Noboru Motoyama
MGI ID: MGI:3038822
Synonyms: Chk2-
Gene: Chek2  Location: Chr5:110839979-110874145 bp, + strand  Genetic Position: Chr5, 53.73 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88888
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 6 kb region including exons 2 to 5 was deleted and replaced via homologous recombination with a neo cassette. Northern blot analysis confirmed the absence of mRNA in homozygotes. (J:88888)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chek2 Mutation:  26 strains or lines available
References
Original:  J:88888 Takai H, et al., Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J. 2002 Oct 1;21(19):5195-205
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory