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Klf5tm1Rng
Targeted Allele Detail
Nomenclature
Symbol: Klf5tm1Rng
Name: Kruppel-like factor 5; targeted mutation 1, Ryozo Nagai
MGI ID: MGI:3038696
Synonyms: Klf5-
Gene: Klf5  Location: Chr14:99298691-99313405 bp, + strand  Genetic Position: Chr14, 49.43 cM, cytoband E2.1
Pressure overload-induced cardiac hypertophy and fibrosis are reduced in Klf5tm1Rng/Klf5+ mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78275
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe 3' end of exon 2 and all of exon 3 were replaced with a neo cassette by homologous recombination. Western blot analysis showed decreased levels of protein in heterozygotes. (J:78275)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klf5 Mutation:  25 strains or lines available
References
Original:  J:78275 Shindo T, et al., Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med. 2002 Aug;8(8):856-63
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory