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Transgene Detail
Symbol: Tg(CMV-Rpgr)1Tili
Name: transgene insertion 1, Tiansen Li
MGI ID: MGI:3038604
Transgene: Tg(CMV-Rpgr)1Tili  Location: unknown  
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(CMV-Rpgr)1Tili expresses 1 gene
Mutation detailsA mouse Rpgr ORF15 variant cDNA was inserted between the cytomegalovirus (CMV) enhancer promoter and the polyadenylation sequence of bovine growth hormone. The cDNA used in this construct is shortened by 654 base pairs in the purine-rich region of the ORF15 exon when compared to the published sequence of the 129/Sv mouse strain. This construct was used to generate transgenic mice by pronuclear injection. Transgene protein accumulates to a much lower level than the endogenous protein and migrated at a size smaller than the native protein. (J:87299)
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:87299 Hong DH, et al., Dominant, gain-of-function mutant produced by truncation of RPGR. Invest Ophthalmol Vis Sci. 2004 Jan;45(1):36-41
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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