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F2rtm1Pago
Targeted Allele Detail
Nomenclature
Symbol: F2rtm1Pago
Name: coagulation factor II (thrombin) receptor; targeted mutation 1, Patricia Andrade-Gordon
MGI ID: MGI:3038377
Synonyms: Par1-, PAR-1-, ThrR-
Gene: F2r  Location: Chr13:95601789-95618433 bp, - strand  Genetic Position: Chr13, 50.21 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38032
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details0.4 kb of genomic sequence encompassing the proximal promoter region and a 5' portion of exon 1 that included the start codon was replaced with a neo cassette inserted by homologous recombination. Normal transcript was undetected in homozygous mutant mice by Northern blot analysis of kidney tissue. (J:38032)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any F2r Mutation:  6 strains or lines available
References
Original:  J:38032 Darrow AL, et al., Biological consequences of thrombin receptor deficiency in mice. Thromb Haemost. 1996 Dec;76(6):860-6
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory