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HhatTg(TFAP2A-cre)1Will
Transgenic Allele Detail
Nomenclature
Symbol: HhatTg(TFAP2A-cre)1Will
Name: hedgehog acyltransferase; transgene insertion 1, Trevor Williams
MGI ID: MGI:3038358
Synonyms: Ap2-Cre, AP-2CRE, CrefaceT
Gene: Hhat  Location: Chr1:192512828-192771219 bp, - strand  Genetic Position: Chr1, 97.55 cM
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Null/knockout, Recombinase)
Mutation:    Insertion
 
Mutation detailsThis transgenic construct consisted of 200 bp of human TFAP2A (TCFAP2A) promoter sequence (encoding a specific enhancer element) followed by NLS-cre, an SV40 polyA signal, and a 1.8 kb TFAP2A genomic fragment extending from within exon 5 through a portion of exon 6. The human intron 5 sequence includes the frontonasal prominence- and limb-specific enhancer. Expression of cre recombinase was detected in the embryonic face and limb mesenchyme. New research has determined that the transgene inserted into intron 9 of the Hhat locus. This insertion creates a non-functional allele. (J:88829, J:190013)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: TFAP2A     Summary of all recombinase alleles driven by TFAP2A.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 31 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hhat Mutation:  4 strains or lines available
References
Original:  J:88829 Nelson DK, et al., Frontonasal process-specific disruption of AP-2alpha results in postnatal midfacial hypoplasia, vascular anomalies, and nasal cavity defects. Dev Biol. 2004 Mar 1;267(1):72-92
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory