Tfap2a^tm2Will
Targeted Allele Detail

Summary

• Symbol: Tfap2a^tm2Will
• Name: transcription factor AP-2, alpha; targeted mutation 2, Trevor Williams
• MGI ID: MGI:3038304
• Synonyms: Alflox, AP-2alpha^lox
• Gene: Tfap2a Location: Chr13:40868778-40891852 bp, - strand Genetic Position: Chr13, 20.01 cM, cytoband A5-B1
• Alliance: Tfap2a^tm2Will page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88826
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 5 and 6 were flanked by single loxP sites in introns 4 and 6. A single frt site remained immediately upstream of the 3' loxP site after the excision of an frt-flanked neo cassette used for selection. (J:88826)

Expression

In Mice Carrying this Mutation:	22 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	21 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tfap2a Mutation: 39 strains or lines available

References

• Original: J:88826 Brewer S, et al., Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects. Dev Biol. 2004 Mar 1;267(1):135-52
• All: 16 reference(s)