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Il4/Il13tm3Anjm
Targeted Allele Detail
Nomenclature
Symbol: Il4/Il13tm3Anjm
Name: interleukin 4; targeted mutation 3, Andrew NJ McKenzie
MGI ID: MGI:3038244
Synonyms: Il-4/13-, Il-4-Il-13-
Gene: Il4  Location: Chr11:53602982-53618669 bp, - strand  Genetic Position: Chr11, 31.97 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89095
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsHomologous recombination results in the deletion of a 15 kb region from exon 3 of the Il13 locus to intron 3 of the Il4 locus. RT-PCR and ELISAs failed to detect any Il4 or Il13 mRNA in activated lymphocytes or protein in stimulated CD4+ T-cells. (J:89095)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il4 Mutation:  23 strains or lines available
References
Original:  J:89095 McKenzie GJ, et al., Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses. J Exp Med. 1999 May 17;189(10):1565-72
All:  55 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory