Tg(Cryaa-cre)10Mlr
Transgene Detail

Summary

• Symbol: Tg(Cryaa-cre)10Mlr
• Name: transgene insertion 10, Mike Robinson
• MGI ID: MGI:3038243
• Synonyms: CPV14/Cre, cry-cre, Mlr10, MLR10-Cre
• Transgene: Tg(Cryaa-cre)10Mlr Location: unknown
• Alliance: Tg(Cryaa-cre)10Mlr page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Cryaa-cre)10Mlr expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cryaa (MGI:88515)

• Mutation details: The expression of sequence encoding cre recombinase was driven by a modified alpha A crystallin promoter. The promoter consists of -282/+43 of the mouse Cryaa gene with an inserted copy of Pax6 consensus binding site in a 5' to 3' orientation at position -86 of the promoter. Seven lines were created with this line having expression of the transgene in both the lens epithelium and lens fiber cells but not in other parts of the eye. (J:88422, J:90292)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cryaa (mouse) Summary of all recombinase alleles driven by Cryaa. Comparative matrix view of recombinase activities Alliance mouse Cryaa gene page

Disease models

Expression

In Mice Carrying this Mutation:

112 assay results 6 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:88422 Ebong S, et al., Characterization of the roles of STAT1 and STAT3 signal transduction pathways in mammalian lens development. Mol Vis. 2004 Feb 19;10:122-31
• All: 56 reference(s)