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Targeted Allele Detail
Symbol: Ightm5Cgn
Name: immunoglobulin heavy chain complex; targeted mutation 5, University of Cologne
MGI ID: MGI:3037892
Synonyms: LMP2AflSTOP
Gene: Igh  Location: unknown  Genetic Position: Chr12, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:88472
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  BALB/c
Allele Type:    Targeted
Mutation:    Insertion
Mutation detailsTo conditionally express the Epstein-Barr virus protein, LMP2A, from either the endogenous weak DQ52 promoter or an inserted strong Igh-V 186.2 promoter, sequence encoding LMP2A was inserted downstream of a loxP-flanked stop cassette. Floxed Igh-V 186.2 promoter sequence was included in the targeting vector between the DQ52 promoter and the floxed stop cassette (which contained frt-flanked neo followed by stop codons). Germline excision of the floxed Igh-V promoter and the stop cassette led to the production of Ightm5.1Cgn. (J:88472)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh Mutation:  33 strains or lines available
Original:  J:88472 Casola S, et al., B cell receptor signal strength determines B cell fate. Nat Immunol. 2004 Mar;5(3):317-27
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.04
The Jackson Laboratory