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QTL Variant Detail
QTL variant: Idd2NON/ShiLtJ
Name: insulin dependent diabetes susceptibility 2; NON/ShiLtJ
MGI ID: MGI:3037558
QTL: Idd2  Location: Chr9:99792386-99792481 bp  Genetic Position: Chr9, cM position of peak correlated region/allele: 52.24 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  NON/ShiLtJ
Allele Type:    QTL
Mutation:    Undefined
    This allele confers resistance to insulin dependent diabetes compared to NOD/Lt. (J:28947)
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).
Idd2 exhibits additive inheritance. Homozygosity for NON/Lt-derived alleles confers reduced rate of diabetes onset.

Mapping and Phenotype information for this QTL, its variants and associated markers


The percentage of circulating CD4+ T Cells in NOD/Smrf mice is 40-50% greater then NON/Lt mice, enabling the investigation of how this quantitative phenotype segregates in a BC1 population (NON/Lt x NOD/Smrf)F1 x NOD/Smrf and in an F2 population (NON/Lt x NOD/Smrf)F1 x (NON/Lt x NOD/Smrf)F1. Statistical analysis using t-tests showed a significant correlation of circulating CD4+ T cells with the mouse Chromosome 9 marker D9Mit12 in both male and female segregants. The gene or genetic region responsible for this phenotype is termed Tlf (T lymphocyte frequency) Importantly, the authors show a correlation of Tlf with diabetic incidence as expressed by NON/Lt and NOD/Smrf mice suggesting that Tlf may in fact be the mouse Chromosome 9 locus Idd2.

Original:  J:28947 Mcaleer MA, et al., Crosses of NOD mice with the related NON strain: A polygenic model for IDDM. Diabetes. 1995 OCT;44(10):1186-1195
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory