About   Help   FAQ
Pou2f2tm1Lmc
Targeted Allele Detail
Nomenclature
Symbol: Pou2f2tm1Lmc
Name: POU domain, class 2, transcription factor 2; targeted mutation 1, Lynn M Corcoran
MGI ID: MGI:3037094
Synonyms: Oct2deltaC
Gene: Pou2f2  Location: Chr7:25087344-25179726 bp, - strand  Genetic Position: Chr7, 13.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88240
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a translational stop codon at the end of the POU homeodomain encoding exon by homologous recombination results a truncated protein. All sequences C-terminal to the DNA-binding domain are removed from proteins translated from this allele. Western blots demonstrated that this truncated protein is produced and stable in vitro. (J:88240)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou2f2 Mutation:  9 strains or lines available
References
Original:  J:88240 Corcoran LM, et al., All known in vivo functions of the Oct-2 transcription factor require the C-terminal protein domain. J Immunol. 2004 Mar 1;172(5):2962-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/16/2017
MGI 6.09
The Jackson Laboratory