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Pou2f2tm1Lmc
Targeted Allele Detail
Nomenclature
Symbol: Pou2f2tm1Lmc
Name: POU domain, class 2, transcription factor 2; targeted mutation 1, Lynn M Corcoran
MGI ID: MGI:3037094
Synonyms: Oct2deltaC
Gene: Pou2f2  Location: Chr7:25087344-25159922 bp, - strand  Genetic Position: Chr7, 13.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88240
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a translational stop codon at the end of the POU homeodomain encoding exon by homologous recombination results a truncated protein. All sequences C-terminal to the DNA-binding domain are removed from proteins translated from this allele. Western blots demonstrated that this truncated protein is produced and stable in vitro. (J:88240)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou2f2 Mutation:  1 strain or line available
References
Original:  J:88240 Corcoran LM, et al., All known in vivo functions of the Oct-2 transcription factor require the C-terminal protein domain. J Immunol. 2004 Mar 1;172(5):2962-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory