About   Help   FAQ
Targeted Allele Detail
Symbol: Pou2f2tm1Lmc
Name: POU domain, class 2, transcription factor 2; targeted mutation 1, Lynn M Corcoran
MGI ID: MGI:3037094
Synonyms: Oct2deltaC
Gene: Pou2f2  Location: Chr7:25087344-25179726 bp, - strand  Genetic Position: Chr7, 13.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:88240
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsInsertion of a translational stop codon at the end of the POU homeodomain encoding exon by homologous recombination results a truncated protein. All sequences C-terminal to the DNA-binding domain are removed from proteins translated from this allele. Western blots demonstrated that this truncated protein is produced and stable in vitro. (J:88240)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou2f2 Mutation:  12 strains or lines available
Original:  J:88240 Corcoran LM, et al., All known in vivo functions of the Oct-2 transcription factor require the C-terminal protein domain. J Immunol. 2004 Mar 1;172(5):2962-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.12
The Jackson Laboratory