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Targeted Allele Detail
Symbol: Tia1tm1Andp
Name: cytotoxic granule-associated RNA binding protein 1; targeted mutation 1, Paul Anderson
MGI ID: MGI:3037091
Synonyms: TIA-1-
Gene: Tia1  Location: Chr6:86381201-86410387 bp, + strand  Genetic Position: Chr6, 37.69 cM, cytoband D2
Germline Transmission:  Earliest citation of germline transmission: J:88770
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of parts of intron 3 and exon 4 of the genomic DNA with a neomycin cassette via homologous recombination. Southern blot analysis confirmed recombination and immunoprecipitation demonstrated that no detectable protein is produced from this allele. (J:88770)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tia1 Mutation:  52 strains or lines available
Original:  J:88770 Piecyk M, et al., TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha. EMBO J. 2000 Aug 1;19(15):4154-63
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory