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Targeted Allele Detail
Symbol: Ddb2tm1Linn
Name: damage specific DNA binding protein 2; targeted mutation 1, Stuart Linn
MGI ID: MGI:3036308
Synonyms: Ddb2-
Gene: Ddb2  Location: Chr2:91211572-91236982 bp, - strand  Genetic Position: Chr2, 50.56 cM, cytoband E1
Tumorigenesis analysis and Hisptopathological images

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:88125
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 4 through 7 were replaced with a neomycin selection cassette via homologous recombination. The absence of expression in homozygous mutant MEFs was confirmed by RT-PCR and Western blot analysis. (J:88125)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ddb2 Mutation:  22 strains or lines available
Original:  J:88125 Itoh T, et al., DDB2 gene disruption leads to skin tumors and resistance to apoptosis after exposure to ultraviolet light but not a chemical carcinogen. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2052-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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