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Ddb2tm1Linn
Targeted Allele Detail
Nomenclature
Symbol: Ddb2tm1Linn
Name: damage specific DNA binding protein 2; targeted mutation 1, Stuart Linn
MGI ID: MGI:3036308
Synonyms: Ddb2-
Gene: Ddb2  Location: Chr2:91211572-91236982 bp, - strand  Genetic Position: Chr2, 50.56 cM, cytoband E1
Tumorigenesis analysis and Hisptopathological images

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88125
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4 through 7 were replaced with a neomycin selection cassette via homologous recombination. The absence of expression in homozygous mutant MEFs was confirmed by RT-PCR and Western blot analysis. (J:88125)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ddb2 Mutation:  22 strains or lines available
References
Original:  J:88125 Itoh T, et al., DDB2 gene disruption leads to skin tumors and resistance to apoptosis after exposure to ultraviolet light but not a chemical carcinogen. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2052-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory