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Targeted Allele Detail
Symbol: Junbtm3Wag
Name: jun B proto-oncogene; targeted mutation 3, Erwin F Wagner
MGI ID: MGI:3036209
Synonyms: junBdelta, junBf
Gene: Junb  Location: Chr8:84976909-84978748 bp, - strand  Genetic Position: Chr8, 41.41 cM, cytoband C2-D1
Germline Transmission:  Earliest citation of germline transmission: J:88126
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed and frt-flanked selection cassette containing both a neomycin resistance gene and a thymidine kinase gene was inserted in the 5' untranslated region. An additional loxP site was inserted 161 bp downstream of the translation stop codon. The neomycin and thymidine kinase genes were subsequently deleted from properly targeted ES cells by transient transfection with a flp recombinase expressing vector leaving the coding sequence flanked by loxP sites. Northern blot and Western blot analysis confirmed the absence of both transcripts and protein product. (J:88126)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Junb Mutation:  12 strains or lines available
Original:  J:88126 Kenner L, et al., Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects. J Cell Biol. 2004 Feb 16;164(4):613-23
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
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