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Grip1tm1Rha
Targeted Allele Detail
Nomenclature
Symbol: Grip1tm1Rha
Name: glutamate receptor interacting protein 1; targeted mutation 1, Ralf H Adams
MGI ID: MGI:3035931
Synonyms: Grip1-
Gene: Grip1  Location: Chr10:119289810-119923172 bp, + strand  Genetic Position: Chr10, 67.33 cM, cytoband D2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88266
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsAn exon encoding the PDZ1 domain was disrupted by the insertion of a neomycin cassette. Protein was undetected by Western blot analysis of whole brain lysates obtained from homozygous mice. (J:88266)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grip1 Mutation:  45 strains or lines available
References
Original:  J:88266 Takamiya K, et al., A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1. Nat Genet. 2004 Feb;36(2):172-7
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory