Lmo4^tm3Sho
Targeted Allele Detail

Summary

• Symbol: Lmo4^tm3Sho
• Name: LIM domain only 4; targeted mutation 3, Stuart Orkin
• MGI ID: MGI:3035916
• Synonyms: Lmo4:LacZ
• Gene: Lmo4 Location: Chr3:143894291-143910981 bp, - strand Genetic Position: Chr3, 68.61 cM
• Alliance: Lmo4^tm3Sho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88168
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ gene was inserted in frame with the translation initiation codon of exon 2 and was followed by a floxed PGK-neomycin resistance gene and thus completely replacing exon 2. Chimeric mice were crossed with cre expressing transgenic mice leading to the excision of the floxed neomycin gene. Beta-galactosidase was expressed from this allele. (J:88168)

Expression

In Mice Carrying this Mutation:

37 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmo4 Mutation: 9 strains or lines available

References

• Original: J:88168 Hahm K, et al., Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1. Mol Cell Biol. 2004 Mar;24(5):2074-82
• All: 2 reference(s)