Tlr6^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Tlr6^tm1Aki
• Name: toll-like receptor 6; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3034062
• Synonyms: TLR6^-
• Gene: Tlr6 Location: Chr5:65109374-65117440 bp, - strand Genetic Position: Chr5, 33.54 cM
• Alliance: Tlr6^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70578
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 1.7 kb of genomic sequence encoding a portion of the extracellular domain was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of homozygous mutant peritoneal macrophages. (J:70578)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr6 Mutation: 50 strains or lines available

References

• Original: J:70578 Takeuchi O, et al., Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol. 2001 Jul;13(7):933-40
• All: 50 reference(s)