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QTL Variant Detail
QTL variant: Leg1LP/J
Name: longevity extending gene 1; LP/J
MGI ID: MGI:3033947
QTL: Leg1  Location: unknown  Genetic Position: Chr8, Syntenic
Strain of Specimen:  LP/J
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


Polymorphic markers were screened in two different complex crosses to identify QTLs associated with increased lifespan. Leg1, a QTL exhbiting significant linkage (P = 5.4 x 10-5) to longevity, was detected on mouse Chromosome 8 in a (LP/J x MOLD/Rk)F1 x (NZW/LacJ x BALB/cBy)F1 population. Leg1 spans approximately 7.5 cM - 12.5 cM on mouse Chromosome 8 and is associated with markers D8Mit290 and D8Mit171. MOLD/Rk-derived alleles confer increased longevity by 110 days at Leg1. On mouse Chromosome 10, a QTL associated with longevity (P = 2.6 x 10-5), Leg2, was identified in a (ST/bJ x C57BL/6J)F1 x (CAST/Ei x DBA/2J)F1 population. Leg2 spans approximately 65 cM - 70 cM on mouse Chromosome 10 and is associated with marker D10Mit267. CAST/Ei-derived alleles confer increased longevity by 110 days at Leg2.

Original:  J:72857 Klebanov S, et al., Maximum life spans in mice are extended by wild strain alleles. Exp Biol Med (Maywood). 2001 Oct;226(9):854-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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